Events

• Conquest of Pskov by Grand Prince Vasili III of Muscovy.
• Formation of the Holy League to defend the Italian States.

Births

• March 30 - Antonio de Cabezón, Spanish composer and organist (d. 1566)
• April 2 - Ashikaga Yoshiharu, Ashikaga shogun (d. 1550)
• Mikael Agricola, Finnish scholar (d. 1557)
• Matsunaga Hisahide, Japanese warlord (d. 1577)
• Oda Nobuhide, Japanese warlord; father of Oda Nobunaga (d. 1551)
• Louis Bourgeois, French composer
• Louis de Morales , Spanish painter
• Bernard de Palissy , French potter and writer
• Ambroise Paré, French surgeon (d. 1590)
• Aloysius Lilius, inventor of the Gregorian calendar (d. 1576)
• Alonso Mudarra, Spanish composer and vihuelist (approximate date) (d. 1580)
• Jean Maillard, French composer
• Jacob Clemens non Papa (Jacques Clément), Franco-Flemish composer
• Pierre de Manchicourt, French composer (approximate date) (d. 1564)
• Juan Bermudo , Spanish composer and organist (approximate date)
• Diego Ortiz , Spanish composer (approximate date)
• Claude Goudimel, French composer (approximate date) (d. 1572)
• Andrea Gabrieli, Italian composer (approximate date)
• Vincenzo Ruffo, Italian composer (approximate date) (d. 1587)

Deaths

• March 10 - Johann Geiler von Kaisersberg, German preacher
• May 17 - Sandro Botticelli, painter of Birth of Venus
• December 31 - Bianca Maria Sforza, daughter of Duke Galeazzo Maria Sforza of Milan and wife of Maximilian I, Holy Roman Emperor
• exact date unknown:
  • Giorgione, Italian painter