Events

• April 11 - Battle of Ceresole - French forces under the Comte d'Enghien defeat Imperial forces under the Marques Del Vasto near Turin.
• May - Emperor Charles V again invades eastern France
• June 19 - August 18 - Imperial siege of St. Dizier in eastern France
• July 19 - September 14 - English forces under Henry VIII besiege and capture Boulogne.
• September 18 - Peace of Crépy - Peace between Charles and Francis. The war between France and England continues.
• October 9 - French forces under the Dauphin assault Boulogne, but are ultimately unsuccessful.
• Italian botanist Luca Ghini publishes the first herbarium
• Founding of the University of Königsberg
• Hungary is invaded by the Turks for the third time and gets robbed of the crown jewels
• First occurrence of rats in North America
• Gustav I of Sweden signs an alliance with France
• Act of Succession: Elizabeth is restored to the Line of Succession to the throne of England

Births

• January 19 - King Francis II of France (d. 1560)
• March 11 - Torquato Tasso, Italian poet
• May 24 - William Gilbert, English scientist,pioneer in the study of magnetism († 1603)
• November 27 - Ascanio Trombeti , Italian composer
• Richard Bancroft, Archbishop of Canterbury (d. 1610)

Deaths

• April 30 - Thomas Audley, English Lord Chancellor
• September 25 - Valerius Cordus, German physician and scientist (* 1515)
• September 10 - Clément Marot, French poet
• Clément Marot, French poet (b. 1496)
• Manco Inca Yupanqui, ruler of the Inca