Science Fair Project Encyclopedia
5-bromouracil
5-bromouracil (or 5-Bromo-2,4(1H,3H)-pyrimidinedione or 5-BrU) is a component of 5-bromo-2-deoxy-uridine.
5-BrU a brominated derivative of uracil that acts as an antimetabolite or base analog, substituting for thymine in DNA and can induce DNA mutation like 2-Aminopurine . It is used mainly as an experimental mutagen, but its deoxyriboside (5-bromo-2-deoxy-uridine) is used to treat neoplasms.
It is said that this base pair will change from a T-A to a G-C after a couple replication cycles. This is because it 5-BrU is often an enol tautomer, that pairs with a guanine.
Characteristics
Molecular formula: C4H3BrN2O2 Molecular weight: 191.0 CAS number: 51-20-7
10-26-2009 08:16:03
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details