Science Fair Project Encyclopedia
Acute tubular necrosis
Acute tubular necrosis may be toxic or ischemic. It presents with acute renal failure to the point that the two concepts are used interchangeably.
Toxic ATN
Histopathology: Toxic acute tubular necrosis is characterized by proximal tubular epithelium necrosis (no nuclei, intense eosinophilic homogenous cytoplasm, but preserved shape) due to a toxic substance (poisons, organic solvents, drugs, heavy metals). Necrotic cells fall into the tubule lumen, obliterating it, and determining acute renal failure. Basement membrane is intact, so the tubular epithelium regeneration is possible. Glomeruli are not affected.
External link
Photo at: Atlas of Pathology
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details