Alfred Louis Olivier Legrand Des Cloizeaux (October 17, 1817 - May 6, 1897) was a French mineralogist.

Des Cloizeaux was born at Beauvais, in the department of Oise. He studied with Jean-Baptiste Biot at the Collège de France. He became professor of mineralogy at the École Normale Supérieure and afterwards at the Muséum National d'Histoire Naturelle in Paris. He studied the geysers of Iceland, and wrote also on the classification of some of the eruptive rocks; but his main work consisted in the systematic examination of the crystals of numerous minerals, in researches on their optical properties and on the subject of polarization. He wrote especially on the means of determining the different feldspars.

Des Cloizeaux was elected as a member of the French Academy of Sciences in 1869, and was its President in 1889. He was awarded the Wollaston Medal by the Geological Society of London in 1886. His best-known books are Leçons de cristallographie (1861) and Manuel de minéralogie (2 vols., Paris, 1862, 1874 and 1893).