The term Anglo-America is used to describe those parts of North America in which English is the main language. It should be noted that this is not a widely used term. It is generally taken to include the United States of America and English Canada. In addition, according to the definition, Belize, Guyana, Jamaica, and several other Caribbean nations belong to Anglo-America despite their geographical proximity to Latin America. Anglo-America would be the American part of the Anglosphere.

In contrast, the adjective Anglo-American is used in two ways:

• It can be used to denote the cultural sphere shared by England or the United Kingdom, the United States, and sometimes English Canada. For example, "Anglo-American culture is different from French culture.". Anglo-Saxon is also used in this sense.

• It can be used to describe relations between England or the United Kingdom on one hand and the Americas, in particular the United States, on the other. For example, "Anglo-American relations were tense before the War of 1812."

As a noun, Anglo-American can refer to an English-speaking person of America. This usage occurs most frequently in the discussion of the history of English-speaking people of the United States and the Spanish-speaking people assimilated into its borders during the Mexican American War. This usage generally ignores the distinctions between people of English, Germans, and other European descent who make up the whole of English-speaking whites in the United States.