The universe of the manga (and OVA) BLAME! is a home to the following fictional characters.

Main Characters

• Killy - the main character of the series. His task of finding a human with the Net Terminal Gene is the basis of the manga's plot
• Cibo - The head scientist of the corporation in the Capitol, Cibo joins Killy on his quest for the Net Terminal Gene.
• Sanakan - A short, young girl with black hair who finds Killy and Cibo in a tunnel after they pierce the impenetrable Megastructure layer with the Gravitational Beam Emitter.

Other characters

Minor characters

• Mensab
• Seu
• Dhomochevsky
• Iko
• Mori - a person whose mind was downloaded into an emergency preservation pack. His corpse sat undisturbed for a long time before Killy stumbled on him. Interestingly, Mori is not his name; we never learn this character's real name. Mori was the name of the manufaturer of the emergency preservation pack, and was printed on the device itself. Killy, acting as a Good Samaritan, takes him along his quest.

Silicon Creatures

• Ivy
• Maeve
• Blon
• Schiff
• Pcell
• Davinelunvega