Bohemund VI of Antioch (1237-1275), was ruler of the principality of Antioch (a crusader state) between 1251 and 1268. He was also count of Tripoli, a title which he retained until his death.

Bohemund VI was the son of Bohemund V of Antioch by his wife Luciana of Segni , niece of Pope Innocent III. In 1254 Bohemund married Sibylla of Armenia, under the truce negotiated by Louis IX of France that ended the power struggle between the two states, started by Bohemund IV, his grandfather. These problems between vassal state and suzerain were put aside by the conflict between the Mameluks and the Mongols. The Mongols were defeated at the Battle of Ain Jalut in 1260, but the Mameluk Baibars began to threaten Antioch, which (as a vassal of the Armenians) had supported the Mongols. Baibars finally took the city in 1268, and all of northern Syria was quickly lost, leaving Bohemund with no estates except Tripoli.

He left a son, Bohemund VII, nominal prince of Antioch and count of Tripoli.