CMS can stand for:

• The Canadian Mathematical Society, a professional society for mathematicians
• The Centre for Mathematical Studies , part of the University of Cambridge
• Changeable Message Sign
• The Chicago Manual of Style, a guide to American English publication style
• C.M.S College (Church Mission Society) , Kottayam, Kerala, India
• The Compact Muon Solenoid detector, a particle physics experiment being built on the Large Hadron Collider accelerator at CERN.
• Content management system - software used to organize and facilitate collaborative content creation
• Color management system
• Cytoplasmic male sterility is a maternally inherited inability to produce functional pollen, it is used in plant breeding to produce hybrids
• Conversational Monitor System, an IBM operating system that runs primarily on mainframe computers
• Code Management System, a software package for performing source code management on computers running the OpenVMS operating system
• Code Morphing Software , a software package for the Crusoe microprocessor which emulates x86-compatible virtual machine
• The Centers for Medicare and Medicaid Services
• CMS-2, a high order language used to program many computers used by the United States Navy
• Cryptographic Message Syntax, a cryptographic standard.
• Color matching system , a system for ensuring that the colors in an image on displayed on a comptuer screen match the printed result.
• Convention on Migratory Species
• Concerned Member State
• The Centre for Musculoskeletal Studies , part of the University of Western Australia

• Additionally, Cms is a minor angel. See list of angels in Enochian.