Carlos Hermosillo (born August 24, 1964 in Veracruz, Veracruz, Mexico) is a Mexican soccer player, the all-time leading goalscorer for the Mexican national team.

Hermosillo started his club career with America during the 1983-84 season. He spent most of his club career in his native Mexico, also playing for Monterrey, Cruz Azul, Necaxa, Atlante, and Chivas. Carlos' best two seasons were in 1994-95 and 1995-96, when he scored 35 and 36 goals respectively for Cruz Azul. Hermosillo made two ventures outside the country: to Belgium's Standard Liège in 1989-90 and to Major League Soccer's Los Angeles Galaxy for two seasons starting in 1998. For the Galaxy, he scored 14 goals and 15 assists in two regular seasons, adding five goals and an assist in the playoffs. Hermosillo retired in 2001.

Hermosillo is tied with Luis Hernández for the all-time goalscoring lead for the Mexican national team with 35 goals (in 90 caps between 1984 and 1997). He played in the 1994 World Cup.