Castleton Corners (or Four Corners) is a neighborhood of Staten Island, one of the five boroughs of New York City, which is the largest city in the United States. It is in a region of the island often referred as Mid-Island.

The word "corners" in the neighborhood's name refers to the intersection of Victory Boulevard and Manor Road, which forms its core. It was once called Centerville, but became more popularly known as Castleton Corners when a post office by the latter name was opened there in 1872. "Castleton" refers to Cassiltowne , County Kildare, Ireland, the birthplace of Thomas Dongan, the colonial governor of the Province of New York after it was obtained from the Dutch — who had called it New Amsterdam — in 1682. The post office later closed, but reopened in 1949, and today it is the general, or main, post office for Staten Island as a whole, its ZIP Code being 10314.

Castleton Corners is separated from its eastern neighbor Sunnyside by Castleton Hill, noted for the two churches that stand across from one another on its western ridge — a Moravian church (Castleton Hill Moravian Church) on one side of Victory Boulevard and a Roman Catholic church (St. Teresa's) on the other. To the north lies West Brighton, with a National Guard armory at the boundary between the two, with Westerleigh and Meiers Corners to the northwest and southwest, respectively, and Todt Hill rising to the south. The Todt Hill public housing project is actually in Castleton Corners in spite of its name.

The corner of Victory Boulevard and Manor Road has long been the center of an important commercial district, although its prominence has declined somewhat in recent decades due to the opening of the Staten Island Mall in 1973. The area had largely been built up by the time the Verrazano-Narrows Bridge opened in November of 1964, meaning that Castleton Corners has been relatively unaffected by the dramatic upsurge in population the bridge's opening largely helped bring about, at least compared with most other neighborhoods on the island.