Charles George (Charlie) Drake (July 21, 1920 – September 15, 1998) was a Canadian neurosurgeon known for his work on treating aneurysms.

Born in Windsor, Ontario, he received his undergraduate and M.D. from the University of Western Ontario.

From 1974 until 1984 he was Chairman of the Department of Surgery at the University of Western Ontario. In 1986, he co-founded the Robarts Research Institute, Canada's only independent medical research centre.

He was the president of the Royal College of Physicians and Surgeons of Canada (1971–1973), the American Association of Neurological Surgeons (1977), the American College of Surgeons (1984–1985), the World Federation of Neurological Societies (1977–1981), the Society of Neurological Surgeons (1980), and the American Surgical Association (1986–1987).

In 1982 he was made an Officer of the Order of Canada and was promoted to Companion in 1998. In 1994 he was inducted in the Canadian Medical Hall of Fame.

He married Ruth Pitts.