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Chiral pool synthesis
Chiral pool synthesis is a strategy that aims to improve the efficiency of chiral synthesis. It starts the organic synthesis of a complex enantiopure chemical compound from a stock of readily available enantiopure substances. The built-in chirality is then preserved in the remainder of the reaction sequence.
Example:
- Chiral Pool Synthesis builds a part of the epothilone molecule (an alternative to Paclitaxel), from readily available enantiopure (-)-pantolactone [1]
references
- [1] Efficient Chiral Pool Synthesis of the C1-C6 Fragment of Epothilones Ulrich Klar, Bodo Röhr, Frank Kuczynski, Wolfgang Schwede, Markus Berger, Werner Skuballa, Bernd Buchmann Synthesis 2005: 301-305
Last updated: 05-29-2005 12:55:52
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details