Clyde Simms (born August 21, 1982 in Jamestown, North Carolina) is an American soccer player, who currently plays defensive midfielder for D.C. United of Major League Soccer.

Simms played college soccer at East Carolina University from 2000 to 2003, where he appeared in 72 games, scoring seven goals and seven assists, and was team captain his final three years. Following his senior season, Simms went undrafted by MLS, and so signed with the Richmond Kickers of the USL First Division.

Although he had a relatively impressive first season with the Kickers, starting 28 games for the club, Simms' talent was not really recognized until he was called into the United States national team camp as a replacement player due to a conflict between the United States Soccer Federation and the players. Simms greatly impressed in camp and, when the disagreement was settled, Simms was asked to remain in camp and train with the regular team.

Simms' performance in the national camp intrigued several MLS teams, and he was eventually signed as a discovery player by D.C. United on February 25, 2005.