Cybersix is the title of an Argentinean comic book, created by Carlos Meglia and Carlos Trillo .

Cybersix (the name comes from the tattoo on her forearm: CYBER 6) was one of five thousand clones created by evil scientist Dr. Von Richter in a South American jungle. Like the other "cybers", she has superhuman strength and agility. When his creations proved disobedient, Dr. Von Richter ordered them destroyed. Cybersix was the sole survivor, and fled to the outside world.

She adopted the identity of a boy killed in a car wreck, Adrian Seidelman, and eventually grew up to become a literature teacher for high school students. She lives alone as a male in the fictitious city of Meridiana.

Like all of Von Richter's creations, Cybersix is dependent on a fluid called "sustenance". When her supply ran out, she was forced to prowl the city, looking for other creatures of Von Richter, such as Fixed Ideas or Technos, that have infiltrated the city. She kills them and takes their sustenace to survive. Almost by accident, she became a superhero by defending the people of her city from Von Richter's schemes, often carried out by his clone "son", Jose. Along the way, she met Data 7, the brain of her brother Cyber 29 in the body of a black panther, and fell in love with biology teacher (also a reporter in the comics) Lucas Amato. Lucas is friends with fellow teacher Adrian Seidelman, not knowing this is Cybersix's alter-ego.

Prowling the city at night for sustenance, Cybersix wears a black bodysuit, a black cape with red lining, a black hat and black fingerless gloves. In the comic, she took her outfit from a Techno prostitute.

There was a live-action TV series made in Argentina as well as a US-Japanese-Canadian animated series (heavily toned-down from the comics, much-reduced violence, the sex and drugs are left out completely.)