Denham is a village in Buckinghamshire, England. It is located just north west of Uxbridge, at junction 1 of the M40.

The village name is Anglo Saxon in origin, and means 'homestead in a valley'. It was listed in the Domesday Book of 1086 as Deneham. The parish church is dedicated to St Mary.

Housing growth has over the years created several Denhams. Modern day Denham Village is a haven for the rich, and is one of the most expensive places in the United Kingdom in which to purchase a house. The retired film actor, Sir John Mills, owns a house here.

Denham Green grew up around the shops beside Denham station on the Chiltern Line; Alexander Korda's film studios, sited between the junction of the Rickmansworth Road (now the A412 North Orbital road ) and Moor Hall Road towards Harefield, provided further employment. One of its more famous residents is Cilla Black.

New Denham grew along the old Oxford Road north-west of Uxbridge, west of the Grand Union Canal.

Higher Denham was built on the site of a First World War army training and transit camp, placed to take advantage of the adjacent Denham Golf Club station. After the War, the camp land was sold off piecemeal for housing, following a similar trend all over Metroland. Martin Baker Aircraft Ltd, manufacturers of aircraft ejector seats, have a small factory in Higher Denham.

Tatling End, Denham is on the Oxford Road, west of the junction with the A412, at the top of the hill leading out of the Misbourne Valley.

Denham is part of South Bucks District, as was formerly the area south of Denham as far as the River Thames. A Boundary Commission decision some years ago moved Slough and its environs to Berkshire, so that the District Council for Denham - South Bucks - found its offices to be in Berkshire as a result. Recently the Council has acquired new offices in Tatling End.

The current eastern boundary with the London Borough of Hillingdon is aligned with the Grand Union Canal. A Boundary Commission proposal to reassign to Hillingdon the area of Denham which lies east of the A412 and south of the A40/M40 was decisively rejected by the residents.

For the administrative convenience of the Post Office, who sort Denham's letters in Uxbridge sorting office, Denham comes under the post town of Uxbridge which gives an address of "Denham, Uxbridge, Middlesex", to the confusion of delivery drivers.

Denham is twinned with Denham in Shark Bay, Western Australia.