Denise Alexander (born November 11, 1939) is a well-known American soap opera actress, most known for her role as Dr. Lesley Webber on General Hospital, a role she originally played from 1973 to 1984.

Alexander first broke into the genre by playing Susan Hunter Martin on Days of Our Lives from 1966 to 1973. A popular actress, much of the show's early success had to do with Susan's rivalry with Julie Olson (played by Susan Seaforth Hayes). In 1973, Susan was written out of the show temporarily when the Days casting office hit a snag renewing her contract. When Susan finally returned, a new actress played her, and Alexander was let go from her contract.

Later that year, she started on General Hospital, playing the role of Dr. Lesley Webber, which would become her most popular and longest-tenured. She stayed with the show for eleven years, leaving in 1984. In 1986, she was offered a big salary to portray absent McKinnon matriarch, Mary, on Another World, a role she played until 1989. Since 1996, she has played the character of Lesley on General Hospital, but only on a recurring basis.