Destiny was a precognitive mutant in Marvel Comics.

Named Irene Adler, she had the ability to see future probabilities and interpret them to best select or manipulate what was likely to happen. She was the long-time lesbian lover of Mystique, and together they raised adopted daughter Rogue. They formed the second Brotherhood of Evil Mutants, a group of ideologically-motivated terrorists, and eventually went to work for the United States government as Freedom Force in exchange for a pardon and protection from anti-mutant sentiment. While on a mission with Freedom Force, Destiny was killed by Legion, who was being influenced at the time by the Shadow King. Most recently, the team of X-Treme X-Men spent some time searching for her diaries of future predictions.

Although the identity of Nightcrawler's father was recently revealed, long-time X-Men writer Chris Claremont had originally intended for Destiny and Mystique to be his biological parents.

Another Marvel character named Destiny fought the Sub-Mariner in the 1960s; this Destiny (real name Paul Destine) was a pawn of Set who was instrumental in causing the Sub-Mariner's temporary amnesia prior to the Silver Age of Comic Books.