Epifanio de los Santos Avenue (EDSA) is a main road in Metro Manila, Philippines. Stretching some 54 km in its original length, it is an important commuting hub between the northern and southern parts of the metropolis. EDSA figures prominently in the recent history of the Philippines for being the site of two peaceful demonstrations that toppled the administration of two presidents, Ferdinand Marcos and Joseph Estrada, as well as a major rally of the political opposition which rocked the earlier months of Gloria Macapagal-Arroyo's term. See EDSA Revolution and EDSA II.

EDSA forms a major portion of one of the circumferential roads in Metro Manila, C-4. It runs in a rough semicircle around the city of Manila and, from the south, passes through the cities and towns of Pasay, Makati, Mandaluyong, San Juan, Quezon City, and Caloocan. Its southern endpoint is at the rotunda near the planned SM Mall of Asia in Pasay and its northern terminus is at Monumento, a monument to Andres Bonifacio, in Caloocan. When the avenue was constructed, it was named Highway 54, but a republic act in 1959 renamed it in honor of Epifanio de los Santos, a noted historian.

The Metro Rail Transit or MRT, Line 3 of the metropolis's railway system, runs along most of EDSA, from Taft Avenue in the south to North Avenue near the SM City Mall in northern EDSA. Future expansion of the MRT will extend it all the way to Monumento.