Gamesley is a village in Derbyshire, England, west of Glossop and north of New Mills. It lies close to the River Etherow which is the boundary with Tameside in Greater Manchester.

Gamesley is the site of a Roman fort, Ardotalia , renamed "Melandra" in the 19th century by an amateur historian. It was one of a string of forts built along the route from Lincoln (Lindum Colonia ) to Chester (Deva). It also lies on the route from Derby (Derventio ) via Buxton (Aquae Arnemetiae ) to Manchester (Mamucium ) It was built about 108 AD in the reign of the Emperor Trajan and abandoned about 150-155 AD.

Gamesley is also, with Hadfield and Glossop, one of the locations used in the cult TV series The League of Gentlemen.

Gamesley Fold Cottage Garden is well-known, with a house dating back to 1650, and is opened to the public every year under the National Gardens Scheme.

Gamesley underwent considerable change in the 1960s, when a large council estate was built, which mainly housed people from Manchester. These housing areas were called 'Overspill Estates', which were also built in other towns surrounding Manchester. The large overspill council estate in nearby Hattersley (in the borough of Tameside) is another example.