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Glutathione peroxidase
The enzyme glutathione peroxidase ( PDB 1GP1, EC 1.11.1.9) is a peroxidase found in the erythrocytes of mammals, which helps prevent lipid peroxidation of cell membranes by consuming free peroxide in the cell. The summary reaction the enzyme catalyzes is:
- 2GSH + H2O2 → GSSG + 2H2O
Where GSH represents reduced monomeric glutathione, and GSSG represents oxidized glutathione. Glutathione reductase then reduces the oxidized glutathione to complete the cycle:
- GSSG + NADPH + H+ → 2 GSH + NADP+
Glutathione peroxidase is a tetramer, and the bovine erythrocyte enzyme has a molecular weight of 84,000. It is a selenium containing enzyme with 4 selenocysteine amino acid residues that participate in the actual mechanism of this enzyme.
See also
- Glutathione reductase
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details


