The Hand of Omega is a fictional device from the British science-fiction television series Doctor Who. It is a remote stellar manipulator invented by the Time Lords of the planet Gallifrey. It was used by the stellar engineer Omega to create a power source that would give the Gallifreyans mastery over time travel. The attempt resulted in a supernova that apparently consumed Omega, but instead shunted him into an antimatter universe. The supernova subsequently collapsed into a black hole, the nucleus of which was harnessed by Omega's colleague Rassilon as the Eye of Harmony, and giving the Time Lords the power to live up to their name.

The history of the Hand after its first use is unknown until its re-discovery by the Doctor. It was removed from Gallifrey by the First Doctor prior to his self-imposed exile before the events of the first Doctor Who episode. He then hid it in a funeral parlour in London in the year 1963, as seen in the 1988 serial Remembrance of the Daleks.

The Hand resided in a casket that gave it a coffin-like appearance. The casket had a dull, bronze appearance to it, but what material it was actually made from is unknown. Seemingly possessed of some basic intelligence, the Hand had the ability to levitate and follow simple orders. It was also able, on the Doctor's orders, to suffuse a baseball bat with energy, which the Doctor's companion Ace then used briefly as a weapon.

In Remembrance, the Seventh Doctor returned to 1963, apparently to move the Hand to another hiding place. In truth, he was laying a trap for the Daleks and their creator, Davros. Davros had hoped to use the Hand to transform the sun of the Dalek homeworld Skaro into a power source for time travel. However, the Doctor had altered the Hand's programming so that instead of enhancing Skaro's sun, the Hand blew it up instead. The resulting supernova wiped out Skaro and, presumably, the Daleks themselves. The Hand of Omega returned to Gallifrey afterward.

In the spin-off novel War of the Daleks by John Peel, it was revealed that the planet Antalin had been destroyed in Skaro's place. This novel, like the others based on the series, is generally not accepted as part of official continuity. Indeed, War was so badly received by fans that some even disavow it within the continuity of the novels.

The Virgin New Adventures novel Lungbarrow by Marc Platt provides some additional history on the Hand during the early years of its creation on Gallifrey. In the BBC Books novel The Eight Doctors by Terrance Dicks it is revealed that there were two Hands, both used by Omega.