Henry D. Hatfield (b. September 15, 1875, d. October 23, 1962) was a Republican politician from West Virginia. He was Governor of the state and he served one term in the United States Senate.

He was born in Logan County, West Virginia on September 15, 1875. He graduated from Franklin College in New Athens, Ohio. He later obtained medical degrees from what is now known as the University of Louisville and then from New York University.

He was then appointed as as surgeon for the Norfolk and Western Railway, based in and also at State Hospital #1 in Welch, West Virginia. He then entered local politics and held various local offices until being elected to the state Senate in 1908. He was elected as governor in 1912. His term was marked by his strict support of the rights of industry relative to labor unions. Following his term (in that era, West Virginia governors could not serve more than one term) he entered the United States Army as a Major in the Medical Corps, serving at a military hospital in Detroit, Michigan.

He was discharged in 1919 and returned to the state. In 1928 he was elected to the Senate. He was defeated for reelection in 1934.

He then settled in Huntington, West Virginia and engaged in the private practice of medicine until his death in 1962.

|- style="text-align: center;" | width="30%" |Preceded by:
Matthew M. Neely | width="40%" style="text-align: center;" |Class 1 U.S. Senator from West Virginia
1929–1935 | width="30%" |Succeeded by:
Rush D. Holt, Sr.