High-energy nuclear physics is a field of study that examines nuclear matter in energy regimes typically delegated to high energy physics. The primary focus of this field is the study of heavy-ion collisions . These types of collisions at sufficient collision energies are theorized to produce the quark-gluon plasma.

Previous high-energy nuclear accelerator experiments have studied heavy-ion collisions using projectile energies of 1 GeV/nucleon up to 158 GeV/nucleon. Experiments of this type, called "fixed target" experiments, primarily accelerate a "bunch" of ions (typically around 10⁶ to 10⁸ ions per bunch) to speeds approaching the speed of light (0.999c) and smash them into a target of similar heavy ions. While all collision systems are interesting, great focus was applied in the late 1990's to symmetric collision systems of gold beams on gold targets at Brookhaven National Laboratory's Alternating Gradient Synchrotron (AGS) and uranium beams on uranium targets at CERN's Super Proton Synchrotron.

Currently, high-energy nuclear physics experiments are being conducted at Brookhaven National Laboratory's Relativistic Heavy Ion Collider (RHIC). The four primary experiments (PHENIX, STAR, PHOBOS, and BRAHMS) study collisions of highly relativistic nuclei. Unlike fixed target experiments, collider experiments steer two accelerated beams of ions toward each other at (in the case of RHIC) six interaction regions. At RHIC, ions can be accelerated (depending on the ion size) from 100 GeV/nucleon to 250GeV/nucleon. Since each colliding ion possesses this energy moving in opposite directions, the maximum energy of the collisions can achieve a center of mass collision energy of 200GeV/nucleon for gold and 500GeV/nucleon for protons.

In the future, high-energy nuclear physics will also be conducted at CERN's new Large Hadron Collider that is projected to be 7 TeV for protons and 2.8TeV for gold.