High Sierra (1941) is a film noir written by John Huston and W.R. Burnett from the novel by W.R. Burnett. Directed by Raoul Walsh. It stars Humphrey Bogart as Roy Earle, Ida Lupino as Marie Garson, Arthur Kennedy as Red Hattery, Donald McBride as Big Mac, and Cornel Wilde as Louis Mendoza.

A gangster, Big Mac, is planning a robbery at a resort casino in California, so he arranges to spring the experienced Roy Earle from prison back East to take charge of the operation. Roy drives across the country to a camp in the mountains to meet up with the two men who'll be working for him. It turns out that one of them has also brought along a runaway young woman, Marie. Roy wants to send Marie back to L.A., but after a few false starts she convinces him to let her stay. He comes to see that she's got more sense and guts than either of the two men, a pair of kids.

Marie is in love with Roy, but her love is not returned. Roy has met a crippled girl, Velma, and her family. It gets under his skin that such a likable girl should be a cripple. He's also in love with her. He pays for an operation to repair her leg, knowing he has no chance with her, and yet hoping.

High Sierra is also a slang term used in computer science to refer to the ISO 9660 standard for storing computer files on compact discs. The standard was created in 1987 when representatives of several major computer hardware manufacturers gathered at a resort near Lake Tahoe known as "High Sierra."