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Hofmann rearrangement
The Hofmann rearrangement is an organic reaction in which a primary amide is converted to an amine upon treatment with bromine and a suitable base. The amide reacts with the base and bromine to form an isocyanate intermediate, which then undergoes hydrolysis to form the corresponding amine. The reaction is so named due to the intramolecular migration of the functional group to the adjacent nitrogen following its deprotonation. It is named after August Wilhelm von Hofmann.
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details