Imipramine (tradenames: Janimine^®, Tofranil^®) is an antidepressant medication belonging to a class called tricyclic antidepressants of the dibenzazepine group, mainly used in the treatment of clinical depression and enuresis.

Imipramine is the first antidepressant to be developed in the late 1950s. It is not as commonly used today but sometimes used to treat major depression as a second-line treatment. It has also seen limited use in the treatment of migraines and ADD.

Some common side effects of the drug include: tremors, dry mouth, blurred vision, constipation, insomnia, drowsiness , perspiration, flushing and weight gain.

Imipramine, a tertiery amine, inhibits the reuptake of serotonin more so than most secondary amine tricyclics, meaning that it blocks the reuptake of neurotransmitters serotonin and noradrenaline almost equally.

Imipramine is converted to desipramine, another TCA, in the body.

External links

• Desipramine - from medicinenet.com