Interstate 185 is located in the city of Greenville, South Carolina. The northern portion, which was built through the central business district, was opened in the 1960s and is cosigned with United States Highway 29. The southern portion, which connects the I-85/I-185 interchange (exit 42) with the I-385/U.S. 276 interchange (exit 30), was opened as a toll road in 2001 ($1.25 per passenger vehicle). This extension was dubbed the "Southern Connector" and increased I-185 from three to seventeen miles in length.

Interstate 185 Exit Numbers and Interchanges

• Interstate 385 North/Mauldin/Greenville (mile 0)
• Interstate 385 South/Columbia (mile 1B)
• Neely Ferry Road/Standing Springs Road (mile 1A)
• Toll Plaza ($.75)
• Fork Shoals Road (mile 4)
• U.S. 25/Augusta Rd (mile 7A/B)
• Toll Plaza ($.75)
• South Carolina 20/Piedmont Highway (mile 10)
• South Carolina 153 (mile 12)
• Interstate 85 (mile 14)
• U.S. 25/White Horse Road (mile 15) (Northbound)
• South Carolina 20 to U.S. 25/Piedmont (mile 16)