John II of Cyprus (died 1458) ruled Cyprus from 1432 to 1458. He was married twice; his second wife was Helena Palaeologus, the daughter of Theodore II Palaeologus, Despot of Morea and his wife Cleope Malatesta. Theodore was a son of Eastern Roman Emperor Manuel II Palaeologus and Helena Dragas .

Upon the death of John II, his only legitimate child Charlotte succeeded to the throne.

John had an illegitimate son, James, whom he appointed Archbishopic of Nicosia at the young age of 16. James did not prove ideal Archbishop material, and was stripped of his title after murdering the Royal Chamberlain. His father eventually forgave him and restored the Archbishopric. James and Helena were enemies, vying for influence over John. After Helena died in 1458, it appeared that John would appoint James as his successor, but John died before he could make it so.