John Ross (October 3, 1790 - August 1, 1866), also known as Kooweskoowe, was a leader of the Cherokee Native American tribe.

He was born near Lookout Mountain, Tennessee, the son of a Scotsman who had gone to live among the Cherokee during the American Revolution. John Ross's mother was 3/4 Scottish as well.

At the age of twenty, after having completed his education, he was appointed as Indian agent to the western Cherokee and sent to Arkansas. He served as an adjutant in a Cherokee regiment during the War of 1812 and participated in fighting at the Battle of Horseshoe Bend against the British-allied Creek tribe.

Ross relocated to Georgia and was chosen as a member of the Cherokee national council in 1817, becoming its president two years later and serving in that capacity for seven years. After this he became assistant chief of the eastern Cherokee, becoming principal chief the following year and serving as such until 1839, participating in the drafting of the Cherokee constitution in 1827.

During his tenure as chief he opposed displacement of the tribe from its native lands, a policy of the United States government known as Indian Removal. However, Ross's political rival Major Ridge signed an unauthorized removal treaty with the U.S. in 1836. Ross unsuccessfully lobbied against enforcement of the treaty, but those Cherokees who did not emigrate to the "Indian Territory" by 1838 were forced to do so by General Winfield Scott, an episode that came to be known as the "Trail of Tears." Accepting defeat, Ross convinced General Scott to have supervision of much of the removal process turned over to Ross.

In the Indian Territory, Ross helped draft a constitution for the entire Cherokee nation in 1839, and was chosen as chief of the nation. He would remain chief until his death.