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Juxtaglomerular apparatus
The juxtaglomerular apparatus is a renal structure consisting of the macula densa and juxtaglomerular cells . Juxtaglomerular cells (JG cells) are the site of renin secretion.
The JG cells are found in the afferent arterioles of the glomerulus act as an intra-renal pressure sensor. Lowered pressure leads to secretion of renin which acts to increase systemic blood pressure via the renin-angiotensin system.
The macula densa senses fluid flow rate in the distal tubule of the kidney and secretes a locally active vasopressor which acts on the adjacent afferent arteriole to decrease GFR.
Last updated: 10-25-2005 20:37:53
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details