In the Star Trek universe, the Khitomer Accords comprised a treaty set down between the Klingon Empire, the United Federation of Planets and the Romulan Empire signed on the planet Khitomer in the year 2293. The accords were formulated after the destruction of the Klingon moon Praxis earlier that year, and whose key purpose was to aid the crippled Klingon Empire out of impending planetary destruction.

Delegates to the Khitomer Conference, held on the Klingon planet Khitomer, included: Rear Admiral Smillie and Admiral Cartwright of the Federation; Ambassador Nanclus and Senator Pardek of Romulus; Ambassador Sarek, the Vulcan envoy to the Federation; Chancellor Azetbur of the Klingon Empire; and various delegates of other planetary nations.

The Khitomer Conference was almost sabotaged by the Klingon renegade General Chang, working in collusion with the Romulan ambassador, the Vulcan Valeris, and Admiral Cartwright. A prototype ship, Pagh, capable of firing photon torpedoes while cloaked, was developed and intended for use in this capacity. However, the Federation starship USS Enterprise destroyed Pagh with Chang on board, and had the other conspirators arrested.

Among the agreements established at the Accords was a ban on subspace weapons.

The Accords were overturned by Chancellor Gowron during the Klingon invasion of Cardassia in 2372, but were reinstated in 2373 when Cardassia joined the Dominion.