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Kolbe-Schmitt reaction
The Kolbe-Schmitt reaction (named after Adolph Wilhelm Hermann Kolbe and J.Schmitt) is a carboxylation chemical reaction and proceeds by heating sodium phenolate (the sodium salt of phenol) with carbon dioxide under pressure (100 atm, 125°C), then treating it with sulfuric acid. The reaction product is an aromatic hydroxy acid of which salicylic acid is a notable example.
References
- H. Kolbe, Ann. 113, 125 (1860); R. Schmitt, J. Prakt. Chem. [2] 31, 397 (1885)
- The Kolbe-Schmitt Reaction Alan S. Lindsey, Harold Jeskey; Chem. Rev.; 1957; 57(4); 583-620.
Last updated: 05-28-2005 22:36:38
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details