Ledburn is a hamlet in the parish of Mentmore, in Buckinghamshire, England.

The hamlet name is Anglo Saxon in origin, and means 'stream with a conduit'. In manorial records of 1212 it was recorded as Leteburn.

The hamlet consists basically of one road of houses. On the northern side of the road are mainly Victorian cottages. There are two 16th century farm houses and Ledburn Manor. The manor house is a 16th century construction built by the Theed family. In the early 18th century it was given a new front facade, in the classical style. It is thought that the small stable block of the manor could in fact have been the original medieval manor.

This hamlet has one claim to fame: it was the nearest place to the location of The Great Train Robbery of 1963, which occurred at Bridego Bridge, Ledburn.

The southern side of the road consists of mainly modern houses. There is one public house 'The Hare and Hounds'. During the 19th century and 20th century the hamlet was owned by Baron Mayer de Rothschild and so subsequently (by inheritance) became part of the Earl of Rosebery's Mentmore estate. The manor house at that time served as the estate office and home of the resident Land Agent . A tiny Methodist chapel in the hamlet has recently been converted to a private house.

The agricultural land in the village, having passed out of the Rothschild's ownership, in the 20th century, is now back in the family's ownership, and part of Sir Evelyn de Rothschild 's Ascott Estate.