The Little Tennessee River is a tributary of the Tennessee River, approximately 135 mi (217 km) long, in the Appalachian Mountains in the southeastern United States.

It rises in the Blue Ridge, in the Chattahoochee National Forest in Rabun County in northeastern Georgia. It flows north through the mountains past Dillard into southwestern North Carolina. It is joined by the Cullasaja River at Franklin, then turns northwest, flowing through the Nantahala National Forest along the north side of the Nantahala Mountains and past Lauada . It crosses into eastern Tennessee and joins the Tennessee River at Lenoir City, 25 mi (40 km) southwest of Knoxville.

The lower river is impounded several places by sequential dams, some created as part of the Tennessee Valley Authority system, forming a string of reservoirs in western North Carolina and eastern Tennessee down to its confluence with the Tenneseee. Near the state line between North Carolina and Tennesse it is impounded by the 480 ft (146 m) high Fontana Dam , completed in 1945, forming Fontana Lake along the southern boundary of Great Smoky Mountains National Park. It is also impounded by Cheoah Dam in North Carolina, and by Calderwood and Chilhowee dams in Tennessee. The reservoirs provide flood control and hydroelectric power. Calderwood diverts water through a tunnel in the montians; its generators are located at the mouth of this tunnel, not at the dam itself. Chilhowee, Calderwood, and Cheoah were originally built by Alcoa to power the aluminum plant at Alcoa, Tennessee. To insure efficency in operation, these dams are now operated by the TVA as part of its system; the TVA then gives Alcoa an amount of electrical power every year equivalent to the amount generated by Aloca's dams. The final impoundment is Tellico Dam, which is just above its mouth into the Tennessee River at Lenoir City, Tennessee. This dam does not have its own hydroelectric generators, but serves to increase the flow through those at nearby Fort Loudon Dam on the Tennessee by means of a canal which diverts much of the flow of the Little Tennessee. This dam was the site of a tremendous environmental controversy during the Ford and Carter Administrations regarding an allegedly endangered species, the snail darter.