Live with Regis and Kelly (1988-2000 title: Live with Regis and Kathie Lee; mid-2000 title: Live with Regis) is an American talk show, hosted by Regis Philbin and Kelly Ripa. The show was formerly known as Live with Regis and Kathie Lee when Kathie Lee Gifford was the co-host, and briefly, Live with Regis when Philbin hosted alone or with several guest hosts, including future co-host Kelly Ripa. The show is aired throughout the US each weekday, either live at 9 am ET (as in its home market of New York City) or a recorded basis.

The show is produced by WABC-TV, where it has aired since 1983. It was known as "The Morning Show" until Buena Vista Television began syndicating it in 1988.

The show features bantering between Regis and Kelly, phone-in contests, and celebrity guests. It is produced by Michael Gelman.

In the UK, the same format is used for the show Today with Des and Mel, hosted by Des O'Connor and Melanie Sykes. Much like its American counterpart, it features celebrity guests, phone-in competitions and chat between the hosts. It is produced by Carlton, and recorded in their London Studios. It can be seen every weekday on one of the UK's terrestrial channels, ITV1, at 5pm - 6pm.

Official 'Today with Des and Mel' website