The Makron is the final boss of the first-person shooter computer game Quake II.

The Makron is the supreme leader of the Strogg , a hostile cybernetic race that invades Earth in the future. Strogg society is ruled by a number of warlords, and the Makron arises from amongst these warlords by a combination of peer selection and brute force. The ultimate goal of Quake II's single-player game is to penetrate the Strogg capital city on their homeworld, and assassinate the Makron. This will cause havoc in the Strogg society, as the remaining warlords (those not killed in the human assault) squabble for power.

The Stroggs are infamous for extensively replacing their body-parts with cybernetic augmentations. The Makron is the most extreme example of this, being nothing more than an organic brain housed inside the chest cavity of a robot-like suit (much like the Teenage Mutant Ninja Turtles villain Krang). Although not particularly imposing (being only slightly taller than the average human), the Makron's robotic body is built for extreme combat; he has a railgun for a head, a hyperblaster for his right arm, and a BFG10K for his left arm. The Makron's body is also extremely durable, having appoximately 4000 hit points, but it has one weakness in that it can be easily knocked down onto its back by powerful weapons fire, such as from a rocket launcher or railgun. The Makron is also very slow, and it's quite easy to pop in and out of cover and shoot him to death with the rocket launcher or railgun.

Not one to fight fair, the Makron always enters battle riding a cyber-organic Jorg battle-suit, which must be destroyed before the Makron itself can be confronted one-on-one.