Among the passages in the Hebrew Bible that have been identified by Christians as prefigurations of the Messiah, the Man of Sorrows of Isaiah 53 is paramount.

The passage survives in three versions, from three autonomous and parallel manuscript traditions: the Masoretic text that is the most familiar one, the Septuagint text, and the Qumran community's Great Isaiah Scroll, one of the Dead Sea Scrolls, dated ca 100 BC.

The "Man of Sorrows" passage of Isaiah 53 is a selected text that usually omits those characteristics of the human scapegoat for the sins of Israel that are not applicable directly to Jesus, or that can only be applied through tortuous applications of allegory, such as "he is as a root in a thirsty land: he has no form nor comeliness; and we saw him, but he had no form nor beauty. But his form was ignoble, and inferior to that of the children of men." (Septuagint version)

Much of the meaningfulness of Joseph of Arimathea's role (q.v. for discussion) hinges upon the words of Isaiah 53:9, "He was assigned a grave with the wicked, and with the rich in his death, though he had done no violence, nor was any deceit in his mouth."

The iconic image that is identified as the "Man of Sorrows" portrays Jesus crowned with the Crown of Thorns just before the Crucifixion.