Margaret Pole (August 14, 1473 – May 27, 1541), Countess of Salisbury, was the daughter of George, Duke of Clarence and Isabella Neville. Her father was a brother of both Edward IV and Richard III.

Born at Farleigh Castle in Wiltshire, she married Sir Richard Pole in 1494. In 1513, her younger brother, Edward, Earl of Warwick, having been executed by King Henry VII of England, she was given the earldom of Salisbury by King Henry VIII.

Margaret was appointed governess to the young Princess Mary, later Queen Mary I of England. However, at the time of the divorce of Mary's mother, Katherine of Aragon, the countess made the mistake of appearing to side with Katherine and Mary against the king, and this was his cue to declare her a traitor. She lost her titles in 1539, following the execution for treason of her eldest son, Henry Pole, Marquess of Montagu .

Eventually she was executed—on May 27 1541 in the Tower of London—by Henry VIII in continuation of his father's program of eliminating possible contenders for the throne. The Countess of Salisbury's execution was a memorable event, as the elderly woman did not go willingly and had to be chased around the block by the executioner. She and her husband Richard Pole had one daughter and four sons, one of whom, Reginald, became Archbishop of Canterbury.