Mark Clayton (born October 13, 1982) is a former American Football wide receiver who played most of his career with the Miami Dolphins, entering the league in 1983 with the Dolphins and playing there until 1992. He finished out his career with the Green Bay Packers, playing a single season with them in 1993. He was born in 1961 and attended the University of Louisville.

A favourite target of Dan Marino, he paired with Mark Duper to form the popular "Marks Brothers". He was a five time Pro Bowl player in 1984, 1985, 1986, 1988 and 1991. He is in the NFL top 50 in receptions (43rd), receiving yards (Tied for 33rd) and receiving TDs (Tied for 13th). He holds Dolphins' records for career pass receptions and TDs, as well as receiving yards in a single season. At one point in time, the Dan Marino-Mark Clayton tandem was the most prolific in NFL history.

Clayton set a National Football League record in 1984 when he caught 18 touchdown receptions. In 2003, he entered the Miami Dolphins Ring of Honor, along with fellow "Marks Brother", Mark Duper.