Mary Frann (February 27, 1943 - September 23, 1998) was an American actress.

Born Mary Frances Luecke in St. Louis, Missouri, her mother involved her with child modeling and at the age of eighteen, she was voted Missouri's "Junior Miss" and went on to win the 1961 national title that earned her a university scholarship. She studied drama at Northwestern University in Evanston, Illinois then worked for a time as the host of a morning television show in Chicago. As an actress, she appeared in a few motion pictures, but worked primarily in television. Mary Frann made her screen acting debut in the television movie "Nightmare in Chicago" which was originally broadcast as an episode of "Kraft Suspense Theatre" in 1963.

From 1974 to 1979 Mary Frann was a regular cast member of the afternoon soap opera, Days of Our Lives but is best remembered for her role as "Joanna Loudon," the wife of Bob Newhart in the popular television sitcom, Newhart that ran from 1982 to 1990. In the years after "Newhart" she worked mainly as a guest star in other series and television movies.

Outside of the entertainment business, Mary Frann was active as a volunteer fundraiser and involved with charitable works. The night before he unexpected passing, she had been working at the Los Angeles Mission, a Christian, non-profit organization dedicated to alleviating the suffering of hungry and homeless men and women on the city's Skid Row.

Mary Frann died in her sleep of cardiac failure at her home in Beverly Hills and was interred in the Holy Cross Cemetery in Culver City, California.