Massachusetts Avenue is the name shared by prominent streets located in Boston, Massachusetts, USA; Washington, D.C., USA; and Lawrence, Kansas, USA. Each Massachusetts Avenue is commonly called "Mass. Ave." by the residents of its hometown.

Washington, D.C.

In Washington, D.C., Massachusetts Avenue is a diagonal avenue running through the city's Northwest, Northeast, and Southeast quadrants. It has an interchange with Interstate 395 near the United States Capitol. It has traditionally been considered to be the northern limit of downtown, although the growth of office space in the city has rendered that distinction largely moot.

Neighborhoods along the avenue include Embassy Row, Dupont Circle, and Capitol Hill. Sites of interest on or near the avenue include Washington National Cathedral, the new D.C. Convention Center, and Union Station. Famous institutions located on Massachusetts Avenue include the Brookings Institution, the Cato Institute, and the Paul H. Nitze School of Advanced International Studies.

Massachusetts Avenue continues west of the city into Bethesda, Maryland, where, in addition to its street name, it is designated Maryland State Highway 396.

Lawrence, Kansas

Massachusetts Avenue is the main street of downtown Lawrence, Kansas. The street takes its name from the Massachusetts Emigrant Aid Company, which founded Lawrence to populate the Kansas territory with free-state (i.e., anti-slavery) advocates.