Muggles is the plural of the word Muggle, used to describe a person without magical abilities in J. K. Rowling's Harry Potter fantasy books and films.

Muggles is a slang term for marijuana, mostly used in the 1920s and 1930s by United States jazz musicians. To muggle or to muggle up was to smoke marijuana, and to experience the "high" from marijuana was to be all muggled up.

"Muggles" is the title of a recording by Louis Armstrong and His Orchestra, recorded in Chicago on December 7, 1928. The title refers to the second meaning; Armstrong was an enthusiastic user of muggles, which was not illegal in most American states at the time. The personnel of this recording were, in addition to Armstrong on trumpet, Fred Robinson, trombone; Jimmy Strong, clarinet; Earl Hines, piano; Mancy Carr (not "Cara" as his name has been too often misspelled) on banjo, and Zutty Singleton on drums. "Muggles" is in the 12 bar blues form. It starts out with some rather modernistic piano work for the times with Singleton playing sensitively on the brushes. Robinson then takes a gutsy lead without breaking the mood, followed by a chorus by Strong showing the influence of Jimmie Noone. The rest of the band then stops for 2 measures while Armstrong starts a chorus on an adventuresome break subtly playing with the rhythm. The horns then play chords behind Armstrong's excellent 2 choruses of solo. The rhythm gently suggests doubletime on the first chorus, giving a sense of acceleration without actually speeding up the tempo, then returns to the dreamy feel of the tune's beginning for the final chorus, with Hines creating fills behind Armstrong.

This was the only side issued from the recording session that day. It is one of the last 4 sides Armstrong made before moving to New York City where, while Armstrong remained magnificent, the bands backing him up were often less interesting, and he switched from recording original compositions to covering popular songs. "Muggles" is regarded as one of Armstrong's masterpieces. It was originally issued on Okeh 8703, a "78" disc in Okeh's "Race record " series. The recording has been reissued numerous times since, and is available on several different compact discs today.

This tune has been covered by later jazz musicians, including Nicholas Payton .