Science Fair Project Encyclopedia
Nine neuramidase subtypes are known, many occur only in various species of ducks and chickens. Subtypes N1, and N2 have been positively linked to epidemics in man.
The neuraminidase enzyme exists as a mushroom-shape projection on the surface of the influenza virus. It has a head consisting of four co-planar and roughly spherical subunits, and a hydrophobic region that is embedded within the interior of the virus' membrane. It is comprised of a single polypeptide chain that is oriented in the opposite direction to the haemagglutinin antigen. The composition of the polypeptide is a single chain of six conserved polar amino acids, followed by hydrophilic, variable amino acids.
Neuraminidase cleaves terminal sialic acid residues from carbohydrate moieties on the surfaces of infected cells. This promotes the release of progeny viruses from infected cells.
- Neuraminidase inhibitors
The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details