Pasquale Stanislao Mancini (March 17, 1817 - December 26, 1888), Italian jurist and statesman, was born at Castel Baronia, in the province of Avellino.

At Naples, where he studied law and displayed great literary activity, he rapidly acquired a prominent position, and in 1848 was instrumental in persuading Ferdinand II to participate in the war against Austria. Twice he declined the offer of a portfolio in the Neapolitan cabinet, and upon the triumph of the reactionary party undertook the defence of the Liberal political prisoners.

Threatened with imprisonment in his turn, he fled to Piedmont, where he obtained a university professorship and became preceptor of the crown prince Humbert. In 1860 he prepared the legislative unification of Italy, opposed the idea of an alliance between Piedmont and Naples, and, after the fall of the Bourbons, was sent to Naples as administrator of justice, in which capacity he suppressed the religious orders, revoked the Concordat, proclaimed the right of the state to Church property, and unified civil and commercial jurisprudence.

In 1862 he became minister of public instruction in the Rattazzi cabinet, and induced the Chamber to abolish capital punishment. Thereafter, for fourteen years, he devoted himself chiefly to questions of international law and arbitration, but in 1876, upon the advent of the Left to power, became minister of justice in the Depretis cabinet. His Liberalism found expression in the extension of press freedom, the repeal of imprisonment for debt, and the abolition of ecclesiastical tithes.

During the Conclave of 1878 he succeeded, by negotiations with Cardinal Pecci (afterwards Leo XIII), in inducing the Sacred College to remain in Rome, and, after the election of the new pope, arranged for his temporary absence from the Vatican for the purpose of settling private business. Resigning office in March 1878, he resumed the practice of law, and secured the annulment of Garibaldi's marriage. The fall of Cairoli led to Mancini's appointment (1881) to the ministry of foreign affairs in the Depretis administration. The growing desire in Italy for alliance with Austria and Germany did not at first secure his approval; nevertheless he accompanied King Humbert to Vienna and conducted the negotiations which led to the informal acceptance of the Triple Alliance.

His desire to retain French confidence was the chief motive of his refusal in July 1882 to share in the British expedition to Egypt, but, finding his efforts fruitless when the existence of the Triple Alliance came to be known, he veered to the English interest and obtained assent in London to the Italian expedition to Massawa. An indiscreet announcement of the limitations of the Triple Alliance contributed to his fall in June 1885, when he was succeeded by Count di Robilant. He died in Rome on the 26th of December 1888.