Paul Friedrich, Grand Duke of Mecklenburg-Schwerin (15 September 1800 - 7 March 1842) ruled as Grand Duke of Mecklenburg-Schwerin from 1837 to 1842.

The son of Hereditary Prince Friedrich Ludwig of Mecklenburg-Schwerin and Grand Duchess Elena Pavlovna of Russia , Paul Friedrich was educated at Geneva, Jena and Rostock, Paul Friedrich became heir-apparent to the throne of Mecklenburg-Schwerin in 1819, upon the death of his father, the Hereditary Prince. In 1837 he succeeded his grandfather, Friedrich Franz I. His reign saw improvements in the infrastructure and judicial system of the Grand Duchy, as well as a change in the government's seat of residence from Ludwigslust to Schwerin. Paul Friedrich died in 1842 of a cold caught while rushing to a fire in his capital city.

In 1822, Paul Friedrich had married Princess Alexandrine of Prussia , by whom he had two sons and a daughter, including his eventual successor, Grand Duke Friedrich Franz II .