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Phosphatidate
Phosphatidates are biochemical compounds that consist of a glycerol backbone, with a (usually) saturated fatty acid bonded to carbon-1, a (usually) unsaturated fatty acid bonded to carbon-2 and a phosphate group bonded to carbon-3.
Synthesis
In mammalian cells, phosphotidates are synthesized in the ER and mitochondrial membrane. The first step in phosphatidate synthesis is the acylation of glycerol 3-phosphate by acyl CoA to form lysophosphatidate. Lysophosphatidate is again acylated to yield phosphatidate. Both of these acylations are catalyzed by glycerol phosphate acyltransferase.
Phosphatidates are precursors for triacylglycerols and phospholipids.
References
- Berg, J.M., J.L. Tymoczko, and L. Stryer, Biochemistry. 5th ed. 2002, New York: W.H. Freeman. xxxviii, 974, [976] (various pagings)
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details