Science Fair Project Encyclopedia
Phospholipase
A phospholipase is an enzyme that converts phospholipids into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C and D.
Phospholipase A (PLA)
Phospholipase A2 catalyses the first step in the formation of arachidonic acid, the precursor of eicosanoids (leukotrienes, prostaglandins). Some eicosanoids are synthesized from diacylglycerol, released from the lipid bilayer by the phospholipase C (see below).The PDB code for phospolipase A2 is 1CJY; the EC code is EC 3.1.1.4.
Phospholipase B (PLB)
- To be written
Phospholipase C (PLC)
- To be expanded
(Bacillus Cereus: PDB 1AH7, EC 3.1.4.3) Phospholipase C is a key enzyme in phosphatidylinositol (PI) metabolism. It is activated by either G proteins (making it part of a G protein-coupled receptor signal transduction pathway) or by transmembrane receptors with intrinsic or associated tyrosine kinase activity. It converts phosphatidylinositol to either inositol triphosphate or diacylglycerol.
10-26-2009 08:16:03
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The contents of this article is licensed from www.wikipedia.org under the GNU Free Documentation License. Click here to see the transparent copy and copyright details



