Port Charles was a soap opera which aired on ABC from June 1, 1997 to October 3, 2003. The show aired 1633 episodes, which included a two-hour pilot which kicked off the series, aired in primetime.

The show was a spin-off of the popular General Hospital. It first featured seven interns in a competitive medical school program. In the first episode, tenured nurse Audrey Hardy (played first on General Hospital by Rachel Ames, who reprised the role on the new serial) was injured and an intern had to operate on her with a power drill to save her life. In the first few years, Port Charles got a reputation for focusing most of its energies on the medical school program, setting more of its main action in Port Charles General Hospital than was seen on the parent show, General Hospital.

Over the years, Port Charles became a soap opera with complex younger characters and ended up focusing on stories about forbidden love, vampires, and resurrection to life after death. The soap opera switched from the regular writing format, instead creating thirteen-week story arcs which are more commonly used on Spanish telenovelas. This allowed the cast, crew, and writing staff to only work six months out of the year.

The show was canceled in the summer of 2003; some fans speculated that it was due to the fact that the show was nominated for Best Daytime Drama and lost at the Daytime Emmy Awards to As the World Turns. In reality, the show, which was owned by ABC, was losing money with each week and was not aired in many parts of the country. This, in turn, brought down ratings and halted revenue.

Since the show only taped for six months out of the year, the remaining episodes were aired with the cast not allowed to return to tape resolutions to storylines. In fact, the final episode was a cliffhanger; heroine Alison (Erin Hershey Presley ) didn't know who the father of her baby was.

Cast of characters

• Lynn Herring as Lucy Coe
• Jon Robert Lindstrom as Kevin Collins
• Kin Shriner as Scott Baldwin (1997-2000, 2001)
• Jay Pickett as Frank Scanlon
• Nolan North as Chris Ramsey
• Julie Pinson as Eve Lambert (1997-2002)
• Lisa Ann Hadley as Julie Devlin (1997-2000, 2001)
• Mitch Longley as Matt Harmon (1997-2000)
• Jennifer Hammon (1997-1999) and Marie Wilson (1999-2003) as Karen Wexler
• Rib Hillis as Jake Marshak (1997-1998)
• Michael Dietz (1997-1999), David Gail (1999-2000) and Alex Mendoza (2000-2001, 2002) as Joe Scanlon
• Debbi Morgan (1997-1998) and Marie-Alise Recasner (1998-1999) as Ellen Burgess
• Renee Griffin as Danielle Ashley (1997-1998)
• Carly Schroeder as Serena Baldwin (1997-2001)
• Sarah Aldrich as Courtney Kanelos (1998-2000)
• Kelly Monaco as Olivia "Livvie" Locke (1999-2003)
• Kimberlin Brown as Rachel Locke (1999-2000, 2001)
• Kiko Ellsworth as Jamal Woods (2000-2003)
• Erin Hershey Presley as Alison Barrington (2000-2003)
• Thorsten Kaye as Ian Thornhart (2000-2003)
• Ion Overman as Gabriela Garza (2000-2002)
• Brian Presley as Jack Ramsey (2000-2003)
• Michael Easton as Caleb Morley (2001, 2002-2003)
• Brian Gaskill as Rafe Kovich (2001-2003)
• Eddie Matos as Ricky Garza (2001-2003)
• Joy Bisco as Casey Leong (2002, 2003)/Marissa Leong (2002-2003)
• Rebecca Staab as Elizabeth Barrington (2002-2003)
• Ian Buchanan as Joshua Temple (2002-2003)