Prime Sentinels are an advanced type of Sentinels. They exist in the Marvel Universe.

The Prime Sentinels were created when Bastion initiated the Operation: Zero Tolerance program. These Sentinels were actually humans who had been fitted with cybernetic nanotech implants which, upon activation, transformed the humans into armored beings with powerful weapons systems. These altered humans set up as "sleeper" agents, unaware of their natures until a signal from the OZT base activated their programming. These Sentinels were used by Bastion to capture Professor X for his own purposes, as well as attack various mutants associated with the X-Men across the country. Bastion and his Prime Sentinels were eventually defeated by the X-Men with help from the government agency SHIELD, who shut down Operation: Zero Tolerance.

One of the more notable Prime Sentinels is Karima Shapandar .